ChiCTR-OOC-17012631
正在进行
盐酸右美托咪定注射液
化药
盐酸右美托咪定注射液
2017-09-05
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成年危重病人
在成年危重病人中使用延長輸注右美托咪定注射液的藥代動力學模型的外部驗證
在成年危重病人中使用延長輸注右美托咪定注射液的藥代動力學模型的外部驗證
在成年危重病人中使用延長輸注右美托咪定注射液的藥代動力學模型的外部驗證
单臂
其它
N/A
N/A
Department of Anaesthesia and Intensive Care, CUHK
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23
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1990-01-01
1990-01-01
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All patients admitted to the Prince of Wales Hospital in Hong Kong expecting to requiring prolonged sedation for more than 24 hours but less than 2 weeks of dexmedetomidine for mechanical ventilation will be included.；
登录查看The exclusion criteria will include the following: history of intolerance to dexmedetomidine, use of centrally acting α2-agonsits or antagonists (eg. clonidine), need for continuous muscle relaxation, uncompensated circulatory failure (mean arterial pressure < 55mm Hg despite vasopressors and inotropes), severe bradycardia (heart rate < 50 beats/min), second or third degree atrioventricular block, severe hepatic impairment (bilirubin > 101 μmol/L), acute severe intracranial or spinal neurologic disorder, significant haematological, endocrine, metabolic or gastrointestinal disease, or burn injuries and other injuries requiring regular anaesthesia or surgery.；
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